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Wednesday, July 29, 2020 | History

2 edition of effect of alloxan diabetes on the course of infection of Trypanosoma lewisi-Kent in albino rats found in the catalog.

effect of alloxan diabetes on the course of infection of Trypanosoma lewisi-Kent in albino rats

Cross, John H. Jr

effect of alloxan diabetes on the course of infection of Trypanosoma lewisi-Kent in albino rats

by Cross, John H. Jr

  • 388 Want to read
  • 2 Currently reading

Published .
Written in English

    Subjects:
  • Alloxan,
  • Diabetes,
  • Diabetes -- Complications

  • Edition Notes

    Statementby John H. Cross, Jr
    The Physical Object
    Pagination53 leaves ;
    Number of Pages53
    ID Numbers
    Open LibraryOL14991576M

    In , scientists closely examined how alloxan caused diabetes in animals. This article was published in Diabetologia and it was entitled “The mechanisms of alloxan- and streptozotocin-induced diabetes.” The researchers stated, “These hydroxyl radicals are ultimately responsible for the death of the beta cells, which have a particularly. Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic Parameters to the Control State by Insulin Treatment Young Hee Choi 1, Myung Gull Lee 1, Inchul Lee 2 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea.

    We used Alloxan monohydrate in dose of 60 mg/kg body weight for induction of diabetes in mice. Seven days after mice were tested for hyperglycemia. Mice were months of age. Lycopene treated rats Figure 2: Effect of Lycopene on Blood Glucose Levels On Day21 In Diabetic Rats Effect of Lycopene on Glycosylated Hemoglobin(HbA 1c):It was observed that at the end of third week after induction of Diabetes, the HbA 1c was significantly higher in Alloxan treated Diabetic rats (prats.

    PDF | On Jan 1, , T. Bulus and others published Acute toxicity effect of the aqueous extract of Terminalia avicennioides on white albino rats | . The effects of alloxan-induced diabetes mellitus on rat ovarian structure and function were examined throughout pseudopregnancy (PSP). Animals received either saline (C) or alloxan (40 mg/kg) treatment on the day of proestrus (PA) preceding PSP or on day 1 (D-1A) of PSP (day 0 = ovulation). Serum samples were analyzed by radioimmunoassay for progesterone (P) and 17 .


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Effect of alloxan diabetes on the course of infection of Trypanosoma lewisi-Kent in albino rats by Cross, John H. Jr Download PDF EPUB FB2

We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. However, we experienced an inconsistent and unpredictable response with alloxan, similar to that discussed by Jain et al.

Healthy adult albino rats ( g) and rabbits ( kg) were used in the by: The aqueous leaf extract of Passiflora edulis () Sims were investigated for its anti-diabetic effect in Wistar albino rats after induction of diabetes ( mg/kg, of alloxan, i.p.). Aqueous extract of (AEPE) at a dose of mg/kg, p.o was administered as single dose per day to diabetes-induced rats for 30 days.

2. Alloxan-induced diabetes. Alloxan-induced diabetes is a form of insulin-dependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals.It has been successfully induced in a variety of animal species; rabbits, mice, rats, monkeys, cats and dogs.Alloxan has been administered in single or multiple doses, through Cited by:   Adult male albino rats of Charles-Foster strain weighing between and g were used.

The animals were fasted overnight and the diabetic state was induced by injecting 12 mg alloxan/ g bogy weight subcutaneously (s.c.). The early and late effects were examined at the end of 1 week and 1 by:   Objective: The present study was designed to determine the neuroprotective effect of Abelmoschus esculentus L.

on alloxan-induced diabetic neuropathy in s: Diabetes was induced in rats. A very warm hello to my dear friends.I am working on diabetic ing to articles I found that suggested dose to induce diabetes 1 in albino rats is about mg/kg.

Effect of the silymarin on the time course of pancreatic malondialdehyde (MDA) during the alloxan-induced diabetes mellitus. Each point represents the mean value ± SEM; n was 8 for each point. ***p alloxan. +++ p. Trypanosoma congolense and Trypanosoma brucei to determine the impact of diabetes on the course of trypanosome infection.

Significant (Palloxan treated rats starting on day seven to the end of the experiment. Trypanosome infection did not affect the glycaemic. Trypanosoma lewisi infections in rat colonies can interfere with research protocols and fleas of wild rats are often the source of such infections.

Currently, diagnosis of T. lewisi in rats is performed by microscopic observation of stained blood smears.

In the course of a research project at CIRDES, a T. lewisi infection was detected in the. causes a state of experimental diabetes mellitus called ‘alloxan diabetes’ [4, 8, 9]. The reduction product of alloxan, dialuric acid [1], has also been shown to be diabetogenic in animals [10, 11], and to cause ultrastruc-tural changes identical to those observed in response to alloxan [6].

Streptozotocin is an antimicrobial agent and has also. Diabetes was induced in Wistar rats (n = 25) by intravenous administration of alloxan (42 mg/kg) and were analyzed at 1, 3, 6, 9 and 12 months after diabetes induction. The hemimandibles were removed and submitted to radiographical and histopathological procedures.

Virulent Trypanosoma lewisi infections in cortisone- treated rats. Journal of Parasitalogy S3,BAWDEN AND STAUBER TALIAFERHO, W. Trypanocidal and re- production inhibiting antibodies to Trypano- soma lewisi m rats and rabbits.

Table Effect of Luff aegyptica leaf extract on body weigh in alloxan induced diabetic rats. Group 0 day 7 day 14 day Diabetic control ± ± ± Diabetic rats + Glibenclamide ± ± ± Diabetic rats + Alcoholic extract ± ± ± Induction of Diabetes.

The animals were fed on normal diet for 7 days of acclimatization. Diabetes was induced by a single dose of mg/kg body weight of alloxan monohydrate in freshly prepared 10 mmol/L sodium citrate, pHintraperitoneally (IP), to rats fasting for at. Diabetes was induced in rats with equal molar dosages of either streptozotocin or alloxan.

The clinical course of the diabetes (mortality, hyperglycemia, weight loss, polydipsia, hyperphagia, polyuria, glycosuria and diabetic indices) was recorded for six weeks before the animals were sacrificed for volumetric quantitation of the pancreatic islets.

diabetic conditions is mainly because of the effect of the diabetogenic agent alloxan. With this method Macedo et al.

() induced diabetes mellitus in experimental rats. The animals were deprived of food for 48 hours, and then weighed and anaesthesized with chloroform in a glass dome.

A solution of 2% alloxan (40mg/kg) diluted in %. Effect of various extracts of C. occidentalis on blood glucose level in alloxan ( mg/kg i.p.)-induced diabetic rats. Acute and chronic treatment of the aqueous extract of C. occidentalis ( mg/kg) in alloxan-induced diabetic rats resulted in a significant (P.

research. In research it is used for induction of Type 1 diabetes. Alloxan is a urea derivative which causes selective necrosis of the β- cells of pancreatic islets [7]. It has been widely used to induce experimental diabetes in animals such as rabbits, rats, mice and dogs with different.

Ghosh S and Suryawanshi SA: Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian Journal of Experimental Biology ; Kumar JN and Loganathan P: Hypoglycemic effect of Spinacia oleracea in alloxan induced diabetic rat. Global Journal of Biotechnology and Biochemistry ; 5(2) The Mechanism of Alloxan and Streptozotocin Action in B Cells of the Rat Pancreas T.

SZKUDELSKI Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland Received November 2, Accepted Ma Summary Alloxan and streptozotocin are widely used to induce experimental diabetes in animals.

Experiment 1 (treatment with alloxan to induce type 2 diabetes). A single dose 84 mg/kg of alloxan Monohydrate (Sigma) dissolved in sterile PBS was used for the induction of diabetes mellitus in an overnight fasted albino Wistar rats through.

Similar degree of glycemia ( mmol/liter) and similar mortality (%) were revealed in August rats exhibiting enhanced activity of NO system and in Wistar rats 3 weeks after alloxan treatment. Under conditions of myocardial ischemia caused by min coronary artery ligation, the intensity of arrhythmias did not differ from the control in Wistar rats with diabetes .The authors studied the ultrastructural appearance and metabolic behaviour of mitochondria in the liver and heart of rats suffering from alloxan diabetes.

Liver mitochondria did not show significant morphological and biochemical changes compared to normal, whereas heart mitochondria were decreased in number, their structure was altered and the phosphorylating activity was .